Soyasapogenol B

CAS No. 595-15-3

Soyasapogenol B( —— )

Catalog No. M24591 CAS No. 595-15-3

Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 170 In Stock
10MG 266 In Stock
25MG 485 In Stock
50MG 695 In Stock
100MG 945 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Soyasapogenol B
  • Note
    Research use only, not for human use.
  • Brief Description
    Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
  • Description
    Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
  • In Vitro
    Cell Viability Assay Cell Line:HCT116, SW480 Concentration:5, 10, 20 μM Incubation Time:24, 48 h Result:Decreased the viability of tumor cells.Western Blot Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the level of caspase-3 and PARP.Decreased the expression of Bcl-2 and increased the expression of Bax.Increased the expression of LC3-II/LC3-I, Beclin 1 and Atg5, decreased the expression of p62.Apoptosis Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the number of TUNEL positive cells.Increased the apoptotic percentage in HCT116 cells by more than 4 folds and 9 folds respectively, elevated to over 10% and 20% in SW480 cells.
  • In Vivo
    Animal Model:Xenograft murine modelsDosage:25 or 50 mg/kg Administration:i.p.Result:Increased the apoptotic cell death dose-dependently.Increased the expression of cleaved caspase-3, Bax, CHOP, GRP78 and LC3BII.Decreased the expression of Bcl-2 and Ki-67.Animal Model:Lipopolysaccharide-induced memory impairment in mice Dosage:10 mg/kg Administration:p.o.Result:Increased LPS-suppressed BDNF expression and inhibited NF-κB activation and TNF-α expression.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    595-15-3
  • Formula Weight
    458.7
  • Molecular Formula
    C30H50O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H](CC(C)(C)C4)O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@@H](O)CC5)CO)([H])CC2)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells.Biol Pharm Bull. 2003 Sep;26(9):1357-60.
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