
Soyasapogenol B
CAS No. 595-15-3
Soyasapogenol B( —— )
Catalog No. M24591 CAS No. 595-15-3
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 170 | In Stock |
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10MG | 266 | In Stock |
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25MG | 485 | In Stock |
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50MG | 695 | In Stock |
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100MG | 945 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSoyasapogenol B
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NoteResearch use only, not for human use.
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Brief DescriptionSoyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
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DescriptionSoyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
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In VitroCell Viability Assay Cell Line:HCT116, SW480 Concentration:5, 10, 20 μM Incubation Time:24, 48 h Result:Decreased the viability of tumor cells.Western Blot Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the level of caspase-3 and PARP.Decreased the expression of Bcl-2 and increased the expression of Bax.Increased the expression of LC3-II/LC3-I, Beclin 1 and Atg5, decreased the expression of p62.Apoptosis Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the number of TUNEL positive cells.Increased the apoptotic percentage in HCT116 cells by more than 4 folds and 9 folds respectively, elevated to over 10% and 20% in SW480 cells.
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In VivoAnimal Model:Xenograft murine modelsDosage:25 or 50 mg/kg Administration:i.p.Result:Increased the apoptotic cell death dose-dependently.Increased the expression of cleaved caspase-3, Bax, CHOP, GRP78 and LC3BII.Decreased the expression of Bcl-2 and Ki-67.Animal Model:Lipopolysaccharide-induced memory impairment in mice Dosage:10 mg/kg Administration:p.o.Result:Increased LPS-suppressed BDNF expression and inhibited NF-κB activation and TNF-α expression.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|Autophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number595-15-3
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Formula Weight458.7
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Molecular FormulaC30H50O3
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H](CC(C)(C)C4)O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@@H](O)CC5)CO)([H])CC2)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells.Biol Pharm Bull. 2003 Sep;26(9):1357-60.
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